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Hyper-Plastic Structural Evolution Of The PEX Domain - A Model Of Evolutionary Exaptation And Neofunctionalization At The Molecular Level
(University of Missouri--Kansas City, 2017)
With the advent of sophisticated genetic, biophysical and in silico technology an
enormous amount of information is being generated regarding the structural, biochemical and
physiological aspects of proteins. Tertiary ...
Discovery of Enzymes Responsible for an Alternate Mevalonate Pathway in Haloferax volcanii
(2014-09-30)
Archaea are a distinct evolutionary domain of microorganisms that contain isoprenoids in ether linkages to glycerol rather than the ester linked fatty acids that characterize membranes of bacteria or eukaryotes. Radiolabeling ...
Structural and functional studies of type three secretion virulence factors from gram-negative pathogenic bacteria
(University of Missouri-Kansas City, 2011-12-21)
Many pathogenic Gram-negative bacteria utilize type III secretion systems (TTSS) to alter the normal functions of target host epithelial cells. Of the 1.1 million deaths that are caused by Shigella each year, nearly a third ...
Involvement of a specific ubiquitin ligase in the assembly of the dynein motor in the filamentous fungus Neurospora crassa
(University of Missouri--Kansas City, 2012-08-27)
Eukaryotic cells utilize multiple molecular motor proteins to accomplish
intracellular transport. The two microtubule based motors, kinesin and cytoplasmic
dynein, work in concert to move cargoes outward and inward, ...
The herpes simplex virus virion host shutoff protein is targeted to mRNA cleavage sites through interactions with components of the host translational apparatus
(University of Missouri--Kansas City, 2011-01-20)
The virion host shutoff protein (Vhs) is a herpes simplex virus (HSV) protein involved in early shutoff of the host cell. It is a component of the infecting virion, located in the tegument region, that works by rapidly ...
Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
(2014)
C. neoformans is an opportunistic fungal pathogen causing fatal meningitis and lung infections. Worldwide every year around 625,000 deaths occur due to Cryptococcosis. A basic understanding of Cryptococcus virulence mechanisms and survival...
Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
(2013)
Calsenilin is calcium (Ca2+) ion Ca2+ binding protein found in the nucleus, plasma membrane, and endoplasmic reticulum of neuronal cells. Calsenilin was first found to interact with two proteins involved in early-onset ...
Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
(2015-08-11)
The primary objective of this project is to develop stereoisomeric prodrugs such as Lvaline-
D-valine-prednisolone (LDP) and D-valine-L-valine-prednisolone (DLP) to improve
ocular and oral absorption of prednisolone. ...
Structural Basis for the Formation of PTPRG•CNTN Complexes in Neural Tissues
(2016)
Receptor protein tyrosine phosphatase gamma (PTPRG) is a cell surface receptor expressed primarily on neurons. It combines cytoplasmic tyrosine phosphatase domains and an extracellular region that includes a carbonic ...
Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
(University of Missouri -- Kansas City, 2018)
Worldwide there are an estimated 1 billion people that are affected by a form of
neurodegenerative disease. The most common forms of neurodegenerative disease are
Alzheimer’s disease and Parkinson’s disease, along ...
Regulation of Antimicrobial Peptide Genes in the Tobacco Hornworm Manduca sexta
(2015-05-26)
The innate immune system, also known as natural or non-specific immune system, is conserved from insects to humans. The insect innate immune system is composed of humoral and cellular components. Insect humoral responses ...
The Role of Host Translation Initiation Factors eIF4H and eIF4A and the Exon Junction Complex in the Control of mRNA turnover and Translation by the Virion Host Shut off Protein of Herpes Simplex Virus
(2013)
During lytic infections, the HSV Vhs endonuclease (UL41) degrades many viral and cellular mRNAs. This endonuclease activity is dependent upon the ability of Vhs to bind the host translation initiation factors eIF4AI/II and ...
Structure-function studies of the staphylococcal complement inhibitor protein family
(University of Missouri--Kansas City, 2012)
Complement is a primary arm of innate immunity that plays essential roles in clearance of microbial invaders and immune complexes, initiation of inflammation, development, and differentiation and serves as a bridge to the ...
Effect of TIMBD on Neurotoxicity Associated with HIV-1 Gp120 and Tat
(University of Missouri -- Kansas City, 2018)
Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND)
is one of the undermining disorders that affects majority of HIV infected patients. Patients
with HAND suffer from both cognitive and motor ...
A proteomic approach for studying LTR retrotransposon host factors in saccharomyces cerevisae
(University of Missouri--Kansas City, 2012-01-20)
The Ty retrotransposons of S. cerevisiae are mobile elements that resemble retroviruses, both in their genetic structures and replication cycles. Ty retrotransposition begins in the nucleus with the transcription of Ty ...
The role of drosophila protein kinase doubletime in circadian period determination, morning and evening oscillators and tauopathy
(University of Missouri--Kansas City, 2012-10-01)
In this dissertation, I used the GAL4-UAS binary expression method to overexpress mutant and wild type forms of the circadian protein kinase DBT in order to address several basic questions about DBT's biological functions. ...
Resveratrol Analogs: Potential Chemopreventive Agents in Breast Cancer
(2015-05-22)
Epidemiological data and studies in rodent models strongly support the role of
estrogens in the development of breast cancers. Estrogens have been added to the list of
known human carcinogens. Exact mechanisms underlying ...
The expression and regulation on antimicrobial peptide genes in insects: studies in the tobacco hornworm manduca sexta
(University of Missouri--Kansas City, 2011-05-10)
Insects have evolved an efficient innate immune system to combat microbes. Most of our knowledge of insect immunity comes from studies with dipteran and lepidopteran insects, such as the fruit fly Drosophila melanogaster, ...
Structure/Function Analysis of Type IIa Receptor Tyrosine Phosphatases on Drosophila Muscle Integrity
(University of Missouri -- Kansas City, 2018)
The Lar-family of receptor protein tyrosine phosphatases (RPTPs); including
Lar, RPTPσ and RPTPδ, are utilized in signal transduction pathways during neural
development. Fundamentally, the processes of axon guidance ...
The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
(2016)
Pathogenic fungi including Candida albicans, cause oral, systemic, and vaginal infections, mostly in immune-compromised individuals. Azoles are the most common antifungals used in treating these infections. The most ...